In a small, early clinical trial, researchers at the University of Chicago Medical Center have found that combining eight ounces of grapefruit juice with the drug rapamycin can increase drug levels, allowing lower doses of the drug to be given. They also showed that the combination can be effective in treating various types of cancer.
For two decades, pharmacists have pasted DO-NOT-TAKE-WITH-GRAPEFRUIT-JUICE stickers on various pill bottles because it can interfere with the enzymes that break down and eliminate certain drugs. This interference makes the drugs more potent. In data presented at the AACR 100th Annual Meeting 2009, the Chicago researchers examine ways to exploit this fruit’s medication-altering properties.
“Grapefruit juice can increase blood levels of certain drugs three to five times,” said study director Ezra Cohen, MD, a cancer specialist at the University of Chicago Medical Center. “This has always been considered a hazard. We wanted to see if, and how much, it could amplify the availability, and perhaps the efficacy of rapamycin, a drug with promise for cancer treatment.”
This trial was designed to test “whether we could use this to boost rapamycin’s bioavailability to the patient’s advantage, to determine how much the juice altered drug levels, and to assess its impact on anti-cancer activity and side effects,” he said.
The study followed 28 patients with advanced solid tumors, for which there is no effective treatment. The dose of the drug increased with each group of five patients, from 15 milligrams up to 35. Patients took the drug by mouth, as a liquid, once a week. Grapefruit juice boosts drug’s anti-cancer effects
NHANES analysis reveals drinking juice is associated with health-promoting behaviors in adults.
Linthicum, MD, April 26, 2009–Pomegranate juice may slow the progression of post-treatment prostate cancer recurrence, according to new long-term research results being presented at the 104th Annual Scientific Meeting of the American Urological Association (AUA). Researchers found that men who have undergone treatment for localized prostate cancer could benefit from drinking pomegranate juice.
New research suggests natural anti-inflammatory power of tart cherries may help relieve post-exercise muscle pain
New Orleans, April 19, 2009 – Drinking at least one glass of low sodium vegetable juice daily may help overweight people with metabolic syndrome achieve better weight loss results. A study, conducted at the Baylor College of Medicine and presented at this week’s Experimental Biology Meeting, found that participants who drank at least 8-ounces of low sodium vegetable juice as part of a calorie-controlled DASH diet lost four pounds over 12 weeks, while those who followed the same diet but drank no juice lost one pound.
Philadelphia, Aug. 19, 2008 — Scientists and consumers have known for years that grapefruit juice can increase the absorption of certain drugs — with the potential for turning normal doses into toxic overdoses. Now, the researcher who first identified this interaction is reporting new evidence that grapefruit and other common fruit juices, including orange and apple, can do the opposite effect by substantially decreasing the absorption of other drugs, potentially wiping out their beneficial effects.